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Scientist III (Morrisville)
By | June 30, 2009
Essential Duties and Responsibilities:
Genetic analysis using the Affymetrix arrays (DMET, 3 IVT and whole transcript gene expression arrays). Excellent skills in experimental design, implementation, troubleshooting, and data analysis. Experience handling large datasets generated from DNA and/or Microarray analysis.
Performs RNA extraction, total RNA quality analysis and cDNA synthesis from a variety of sources including FFPE tumor samples using approved standard operating procedures.
Perform absolute and/or relative quantification of gene expression levels using real-time PCR methods.
Review of gene expression data, gene expression protocols and final reports.
Performs DNA purification and quantification, gel electrophoresis, and normalization. Performs routine and non-routine genotyping assays including DNA sequencing, gel based assays and endpoint analysis.
Performs the laboratory portion of the assay development and validation process with including optimization of PCR conditions.
Assay design for the detection human genetic variations using bioinformatic software and other appropriate resources.
Perform literature searches in support of the scientific efforts at Gentris.
Develops protocols and methods for evaluating and analyzing various types of genomics data.
Assists in the writing, editing, and implementing standard operating procedures, material requirements documents, and other essential documentation.
Mentoring and training staff in the junior scientists positions.
Communicate ongoing project/study progress and act as the key interface to clients.
Qualifications:
Minimum requirements include a Biological Science degree (BS+4, MS+2) with Industry experience, Biotech / Pharmaceutical / Drug Discovery. Candidates must have working experience with molecular biology techniques, and knowledge of advanced molecular biology techniques especially with RNA. Must be detail-oriented. Ability to think and work independently.
Topics: Raleigh-Durham PCR jobs |
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