TECHNICIAN/RESEARCH ASSISTANT POSITION (Boston University)
By | September 2, 2010
TECHNICIAN/RESEARCH ASSISTANT POSITION IN MOLECULAR BIOPHYSICS LABORATORY
We seek an experienced, motivated and creative individual to join the Molecular Biophysics Laboratory in the Physics Department at Boston University to work with a team of graduate and postdoctoral
researchers in the area of membrane protein biophysics with specific focus on Spectroscopic studies of animal and microbial rhodopsins.
Candidates for Technician/Research Assistant positions should have a BS or an MS in Biological Sciences and strong skills in molecular biology and basic laboratory techniques.
Experience in PAGE, PCR, gene cloning and mutagenesis as well as experience with in vitro cell- free protein expression and in vivo protein expression will be an advantage.
We look for strong organizational abilities, conscientious laboratory skills and ability to work in a goal-oriented team environment.
One to four years of post-graduate laboratory experience is desirable.
Please send your resume and list of three references by email to:
Prof. Kenneth J. Rothschild
Director, Molecular Biophysics Laboratory, Department of Physics, 590
Commonwealth Avenue, Boston University, Boston, MA 02215
Boston University is an Equal-Opportunity/Affirmative-Action Employer. Women and minorities are encouraged to apply.
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RESEARCH TECHNICIAN I (MGH)
By | September 2, 2010
We are seeking a highly motivated and skilled individual for this entry-level laboratory technician position. They will be required to acquire and process patient tumor samples. This requires that they have technical ability in tissue culture, which will be essential. Knowledge of molecular biology techniques is preferable, as you will be required to purify DNA, RNA, run western blots and PCR reactions. You will also be required to work independently in the execution of high throughput screening.
Please send your resume to KOHANLON@PARTNERS.ORG
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QUALITY CONTROL SCIENTIST (Medford, MA)
By | September 1, 2010
HEPREGEN CORPORATION (Medford, Massachusetts)
Hepregen Corporation (200 Boston Ave, Suite 1500, Medford, MA 02155, www.hepregen.com) is a venture-backed startup out of the Massachusetts Institute of Technology focused on commercializing a portfolio of liver tissue engineering technologies. Hepregens mission is to provide innovative bioengineering solutions to the biotech and pharmaceutical industries in order to improve the success and economics of drug development. Its first product platform (HepatoPacTM) is a micro-liver platform for advanced toxicity screening and drug discovery.
Primary Responsibilities / Reporting Requirements: Assist in setting up cell culture quality operations, including developing cell based assays, image analysis and statistical analysis protocol. Collect and analyze data from production batches using standard spreadsheet and statistical software packages. The position is open for a daytime shift. This position reports directly to the VP Operations, but coordinates and interacts with the R&D organization.
Degree Requirement / Prior Experience: Bachelors degree in a scientific or engineering discipline with prior experience working in a laboratory. Mammalian cell culture experience is highly desirable. Quality Control experience including cell based assays (e.g. ELISAs, colorimetric assays, and PCR), aseptic cell culture techniques, analytical testing, microscopy and statistical data analysis is a plus.
Key Personality Traits: Goal-oriented, highly motivated, strong work ethic, can troubleshoot problems with a hands-on approach, willing to learn new concepts/techniques, and can communicate results effectively in an interdisciplinary team.
Compensation: Hepregen offers competitive pay, a high growth environment, and a benefits package that includes stock options as well as participation in health and dental plans; 401(k) retirement plan; life insurance; and disability coverage.
Please send cover-letter and resume to: careers@hepregen.com
Hepregen Corporation located at 200 Boston Avenue, Medford MA 02155 is an equal opportunity employer. All candidates must be legally available to work in the United States.
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Sr Research Associate I – Viral Genomics (Cambridge, MA)
By | August 31, 2010
OVERALL RESPONSIBILITY
This position requires scientific knowledge, technical expertise, creativity and outstanding practical laboratory skills to design and execute projects within the Molecular Biology Research & Development of the Genome Sequencing and Analysis Program. Projects will focus on developing novel methods for multiple viral genome sequencing projects as part of a larger collaborative enterprise. Research will concentrate on, but is not limited to, optimization of sample preparation and library construction, technology development and pilot studies for determining the genome sequence of viruses from RNA and DNA templates using new sequencing technologies. The candidate will work collaboratively with the Broad’s viral genomics team, sequencing platform, and external collaborators to complete project goals. The successful candidate will possess a broad general knowledge of molecular biology and specific technical knowledge of molecular cloning techniques, and solid experience working with RNA. The ideal candidate will have experience working with RNA viruses. In addition, the candidate will adapt easily to changing needs and priorities of a fast-paced research environment, facilitate project completion, address technical problems, help determine the methods to be used in research, and summarize and present project results.
CHARACTERISTIC DUTIES
• Uses specialized technical knowledge, creativity and practical skills in molecular biology to plan, design and execute laboratory projects that support the overall research goals of the Genome Sequencing and Analysis Program
• Develops and uses qualitative and quantitative assays to define basic parameters of library construction and sample preparation steps. Will work directly with infectious viral samples in a BL2+ setting. Tests and optimizes novel approaches that have the potential to overcome current bottlenecks and limitations of library construction and sample preparation for next-generation sequencing instruments
• Carries out laboratory processes, analyzes results and addresses technical problems. Presents results to the Molecular Biology Research & Development group and viral genomics team, and participates in the design of follow-up experiments
• Coordinates with other research staff to facilitate the completion of pilot studies and monitors the progress of projects. When required works directly with external collaborators.
• Assists in implementing changes in protocols or methods and may assist with the training of lab personnel on new methodologies
• Consults scientific literature and collaborates with other researchers from the scientific community as needed
• Maintains lab records and complies with all safety, biohazard and radioactivity guidelines
QUALIFICATIONS
• Bachelor’s degree in biology or related field required with 4 years of working experience, or Master’s degree with a minimum of 2 years working experience required, or equivalent combination of education and experience.
• At least 4 years lab experience in Molecular Biology, Genomics, or a related field required
• Solid technical knowledge and hands-on experience with molecular biological methods such as DNA & RNA purification, cDNA synthesis, enzymatic manipulation of DNA & RNA, PCR, sequencing, molecular cloning, and library construction
• Must have significant experience working with RNA
• Experience with viral research is preferred
• Experience with sequence analysis tools and genomics databases is a plus
• Strong organizational and time management skills required
• Must be able to work independently as well as part of a team in a fast-paced environment
• Creativity, scientific curiosity, and the desire and ability to improve existing technology preferred
• Excellent communication skills and the ability to interact professionally with all levels of staff required
The Broad Institute was launched to pioneer a new model of collaborative biomedical science that would transform medicine. To accomplish these goals, we have built an amazing team of talented Broadies who work together to realize this transformation.
We are always looking for new Broadies to join our team and help us tackle important problems at the cutting edge of science.
The Broad community includes professional scientists from many disciplines, administrative staff, and students. We seek to cultivate an interdisciplinary, goal-oriented work environment that unleashes scientific creativity and empowers our people to pursue ambitious and critical projects.
Our work transcends traditional academic boundaries, giving Broad employees and affiliates access to an unparalleled biomedical research community across the Harvard and MIT communities and beyond.
The Broad Institute is committed to providing its employees with a competitive compensation and benefits package. We recognize the need for our employees to have a balance between work and personal life. To that end, our benefit plans and options reflect our desire to promote an environment that supports the health, diversity, and general wellbeing of our employees.
All Broadies also have access to world-class research and state of the art technology and are fully supported in their professional development, pushing the envelope for further growth.
The Broad Institute is an equal opportunity employer.
If interested, please apply online at http://track.tmpservice.com/ApplyClick.aspx?id=968154-1857-6939
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RESEARCH ASSOCIATE (Medford, MA)
By | August 31, 2010
HEPREGEN CORPORATION (Medford, Massachusetts)
Hepregen Corporation (200 Boston Ave, Suite 1500, Medford, MA 02155, www.hepregen.com) is a venture-backed startup out of the Massachusetts Institute of Technology focused on commercializing a portfolio of liver tissue engineering technologies. Hepregens mission is to provide innovative bioengineering solutions to the biotech and pharmaceutical industries in order to improve the success and economics of drug development. Its first product platform (HepatoPacTM) is a micro-liver platform for advanced toxicity screening and drug discovery.
Primary Responsibilities / Reporting Requirements: Implements and runs cell-based assays to characterize and validate liver culture models for screening drug metabolism and toxicity in collaboration with industrial partners. Analyzes data from experiments using statistical software packages. Prepares data summaries for dissemination to the group. Participates in technology development in liver tissue engineering. Exercises judgment within defined procedures to determine appropriate experimental action, and works on problems of moderate scope where analysis of data requires a review of identifiable factors. Works to further refine protocols for cell culture and downstream assays. Reports directly to Director, Research.
Degree Requirement / Prior Experience: Bachelors or higher degree in a scientific or engineering discipline with at least one (1) year of experience working in academic or industrial setting. Mammalian cell culture experience, especially with primary liver cells (i.e. hepatocytes), is highly desirable. Basic knowledge of cell-based immunoassays (ELISAs, Western blots, colorimetric assays), PCR and aseptic technique using bio-safety cabinets is required.
Key Personality Traits: Goal-oriented, highly motivated, strong work ethic, can solve problems with a hands-on approach, willing to learn new concepts/ techniques, can communicate research effectively in an interdisciplinary setting, and comfortable working in a start-up environment with an entrepreneurial mindset.
Compensation: Hepregen offers competitive pay, a high growth environment, and a benefits package that includes stock options as well as participation in health and dental plans; 401(k) retirement plan; life insurance; and disability coverage.
Please send cover-letter and resume to: careers@hepregen.com
Hepregen Corporation located at 200 Boston Avenue, Medford MA 02155 is an equal opportunity employer. All candidates must be legally available to work in the United States.
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Ph.D. Protocols Scientist position at Molecular Diagnostic Compnay (Cambridge/Boston)
By | August 24, 2010
Scientist – Protocols
Good Start Genetics is searching for a Scientist / Sr. Scientist who will serve an integral role developing molecular protocols for a DNA sequencing-based genetic diagnostic platform. This position will work closely with the Director of Technology to develop and automate novel sample-preparation protocols for next-generation DNA sequencing.
Responsibilities
Transition molecular protocols from working prototypes into robust automated assays.
Design custom workflows on a high-throughput liquid handling robotics platform.
Generate and maintain standard operating procedures for protocols developed.
Analyze results of next-generation sequencing-based experiments, in collaboration with the computational team when necessary.
Prepare reports for publication and internal use, documenting techniques and methods used.
Work collaboratively as part of a small, interdisciplinary team of biologists, doctors, geneticists, computer scientists, and mathematicians / statisticians.
Develop new strategies for analyzing and presenting genetic sequencing data.
Work efficiently in a fast-paced startup environment.
Qualifications
PhD in genetics, molecular biology, related discipline, or equivalent industry experience.
Proven track record developing/automating novel protocols utilizing polymerase, ligase, nuclease, and restriction enzymes.
Extensive experience developing high-throughput workflows for laboratory automation.
Experience writing scripts to control liquid handling robots.
Deep mechanistic understanding of standard molecular techniques including real-time PCR, molecular cloning, DNA shearing, adapter ligation/purification.
Industry experience (e.g., product development and commercialization), especially in the clinical diagnostics space, a strong plus.
Ability to independently analyze large datasets, e.g. from a next-generation DNA sequencer, a strong plus.
Willingness to work in a start up environment. Proven teamwork and leadership skills. High creativity. Excellent communication skills and attention to detail.
Company Overview
Based in Boston, Good Start Genetics Inc. is developing a genetic diagnostic for the reproductive market. The diagnostic will be completed in a CLIA certified laboratory and be distributed through fertility clinics. Good Start Genetics has recently received its first round of institutional financing and is looking to build its team with experienced life science professionals.
To learn more or apply for this position, please email Greg Porreca: gporreca@gsgenetics.com
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Research Technician (Boston)
By | August 23, 2010
The Howard Hughes Medical Institute, a leading biomedical research organization, conducts scientific research in leading academic medical centers. We offer competitive salaries and an excellent, flexible benefits package which includes health, dental and vision insurance, generous personal time off, and employer contributions to a 403(b) retirement program with immediate vesting.
Job Summary:
An exciting opportunity exists to join a laboratory at Harvard Medical School investigating the mechanisms that regulate brain cells and the connections between them. The goal of the research is to understand how the brain rewires itself to store information and how these processes go awry in human disease.
The Research Technician position provides excellent opportunities for continued scientific learning and development. It is an ideal role for a candidate who is interested in working for a minimum of a few years in the laboratory.
Principal Responsibilities:
Perform dissection of tissue from embryonic mice to generate dissociated neuronal cultures
Biochemical and molecular biology experiments including western blotting, RNA purification, and cDNA preparation
Mouse colony maintenance. Includes breeding, culling and genotyping
Contribute to lab organizational matters such as ordering supplies, maintaining stocks and overseeing equipment
Preferred Qualifications:
B.S. and/or M.S. in Biology, Biochemistry, or Neuroscience
Knowledge of basic genetics and molecular biology
Training in animal husbandry and PCR genotyping
Training in mammalian cell culture techniques
Western blotting
Strong organizational and record keeping skills
Familiarity with database software such as Excel or Filemaker
Must be a team player able to interact effectively with a large group and work independently with little supervision
HHMI is not able to provide sponsorship for employment. All applicants must be legally eligible to work in the United States.
To Apply:
Please send cover letter, CV, and three references to: Bernardo Sabatini, Ph.D., Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, MA 02115. Email: sabatinilab@gmail.com. No phone calls please.
To learn more about the lab, refer to our website at:
http://neuro.med.harvard.edu/faculty/sabatini.html
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Molecular Biologist (Medford, MA)
By | August 19, 2010
Agrivida is an agricultural biotechnology company based in Massachusetts and Connecticut developing products and processes that convert biomass into biofuels. We continue to build a team of experienced plant scientists, molecular biologists, biochemists, and chemical engineers with varied backgrounds and experiences to play key roles in establishing the foundation of our plant biotechnology and bioprocessing capabilities.
Agrivida seeks qualified persons to join our Gene Development group located in Medford, MA as a Molecular Biologist. The ideal candidate would have experience in the following areas:
* Molecular Biology (cloning, PCR, Western, DNA sequence analysis)
* Performing Enzyme Assays
* Excellent communication skills, both oral and written
Applicants should have a B.S. or M.S. in biology, molecular biology, or a related field with at least two years experience working in a laboratory setting. Applicants must demonstrate their abilities to work at the bench. Excellent organizational skills and computer literacy is required. To apply, please send cover letter and curriculum vitae to careers@agrivida.com with the subject line “Molecular Biologist”
Agrivida is an equal opportunity employer.
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Molecular Biology Research Technician (Boston/Cambridge)
By | August 18, 2010
Good Start Genetics is searching for a Research Technician who will serve an integral support role developing molecular protocols for a DNA sequencing-based genetic diagnostic platform. This position will work closely with Scientists and the Director of Technology to develop novel protocols for next-generation DNA sequencing.
Responsibilities
Assist Scientists with experiments developing multiplex target capture, next-generation sequencing library preparation, and novel next-generation DNA sequencing applications.
Run, and help to design, custom workflows on a high-throughput liquid handling robotics platform.
Run a next-generation DNA sequencing instrument.
Maintain, and help to generate, standard operating procedures for protocols developed.
Document techniques and methods used, and help prepare reports for publication and internal use.
Maintain / manage laboratory supply inventory
Work collaboratively as part of a small, interdisciplinary team of biologists, doctors, geneticists, computer scientists, and mathematicians / statisticians.
Work efficiently and independently in a fast-paced startup environment.
Qualifications
BS/BA in Biology or related discipline.
Experience / familiarity with standard molecular techniques including real-time PCR, molecular cloning, DNA shearing, adapter ligation/purification.
Understanding of genomic technologies, including next-generation sequencing and library preparation methods, considered a plus
Experience using / programming laboratory automation considered a plus.
Strong organizational skills.
Willingness to work in a start up environment. Proven teamwork and leadership skills. High creativity. Excellent communication skills and attention to detail.
Industry experience (e.g., product development and commercialization) a plus, especially in the clinical diagnostics space.
Company Overview
Based in Boston, Good Start Genetics Inc. is developing a genetic diagnostic for the reproductive market. The diagnostic will be completed in a CLIA certified laboratory and be distributed through fertility clinics. Good Start Genetics has recently received its first round of institutional financing and is looking to build its team with experienced life science professionals.
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Tissue Culture Technician (Boston, MA)
By | August 18, 2010
The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances. For more information, visit: http://wyss.harvard.edu/.
The Wyss Institute for Biologically Inspired Engineering at Harvard University seeks a talented, enthusiastic and experienced individual to work as a cell culture technician providing services to Institute researchers and faculty in its Biomimetic Microsystems Platform. Working under the supervision of the Platform Leader, and reporting to the Operations Director, this person will establish and manage a large mammalian and microbial cell culture laboratory including ordering all supplies and maintaining shared stocks; isolate and culture primary living cells from mammalian whole organs and human tissues; maintain various primary and established cell lines in culture; teach sterile tissue culture techniques to students, fellows and staff; carry out cell sorting; and assist in studies involving cells cultured in a variety of engineered microsystems technologies. Collaboration with other Wyss personnel to achieve objectives and enhance service quality is expected. The successful candidate will accurately and thoroughly document experimental observations and protocols, as well as maintain the Biomimetic Microsystems Platform’s laboratory space in terms of compliance and supplies.
B.A./B.S. in biological science, such as cell biology, immunology, molecular biology or biochemistry, is required. 5 years or more of experience in mammalian and microbial cell culture and use of standard molecular biology techniques, such as DNA sequencing, PCR, cloning, and protein expression. Knowledge of molecular cell biology and experience with light and fluorescence microscopy are required. Experience at isolating living cells from whole mammalian tissues and organ explants and establishing primary cells in culture is required. Prior experience establishing and managing a multi-user tissue culture laboratory strongly preferred. Proficiency with personal computers and applicable software packages (Microsoft Word, Excel) is a must.
If interested, please apply online at http://track.tmpservice.com/ApplyClick.aspx?id=961097-1857-8239
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