Research Scientist / In Vivo Pharmacology (Cambridge)
By | January 5, 2009
Peptimmune, a biotechnology company located in Cambridge and developing therapeutics for the treatment of autoimmune and infectious diseases, has an opening for an energetic individual to support our in vivo pharmacology/immunology group.
This group evaluates lead/experimental compounds in PK/PD studies and in in vivo efficacy models of autoimmune disorders, including experimental autoimmune encephalomyelitis (EAE), rheumatoid arthritis, and inflammatory bowel disease.
In this position the candidate will be expected to design as well as execute in vivo research studies, help in the development of new in-house disease models, write study reports of scientific findings, and participate in scientific discussions about relevant immunologic topics.
Major Duties and Responsibilities
- Initiate, design, direct, and execute preclinical in vivo scientific research critical for group/company objectives and goals
- Show technical expertise in all aspects of in vivo pharmacology and capable to train team members in (but not limited to):
- Handling and dosing of rats, mice, and guinea pigs using various routes of administration (IV, PO, SC, IM, ID, IP)
- Induction and development of experimental models of disease (such as EAE, CIA, IBD)
- Assessment of animals (such as clinical observations, health checks, and disease scoring) during the course of a study
- Aseptic collection of blood and various tissue types for ex vivo analysis
- Initiate and implement processes which will focus on the cross training of all animal facility personnel to enable interdisciplinary collaboration and ensure experimental consistency
- Identify and initiate new disease models to test the efficacy of lead compounds
- Review relevant literature to stimulate new ideas and aid in expanding current research platform
- Coordinate cross departmental collaborative work
- Supervise members of in vivo pharmacology/immunology group
- Write SOPs, procedure guidelines, and animal care and use protocols
- Write study reports and be proficient in graphing software (Prism)/statistical analysis
- Write and present scientific findings at conferences as well as assist in preparing manuscripts for publication
Required Competencies
The candidate must have technical expertise in all aspects of in vivo pharmacology specifically experience with in vivo animal models of autoimmune diseases including different routes of compound administrations, immunizations, and model development. The candidate must be fluent in English with excellent written and verbal communication skills and have strong organizational skills. Successful candidates should exhibits a good degree of scientific reasoning and be capable to troubleshoot problems if they arise. The candidate should show enthusiasm and willingness to learn in a dynamic fast-paced growing environment. The candidate should be capable of working in a team setting, however able to execute projects independently. The candidate must also be willing and able to share weekend work duties with other members of the team.
Experience in one or more secondary skills would be a plus (however not required)
RT-PCR (Taqman technique and/or Applied Biosystems 7300 instrumentation), histology experience, protein/antibody purification, and/or SDS PAGE and western blot experience.
Education Required
Potential candidates must possess a PhD in immunology, pharmacology, or relevant field with at least 2 years of post-graduate experience or MS with at least 8 years of experience in biotechnology or pharmaceutical industry in an in vivo pharmacology. He/she should be authorized to work in the US without restriction.
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Research Assistant (HMS/BIDMC) (Longwood Medical Area)
By | December 22, 2008
Postdoctoral researcher at Harvard Medical School and Beth Israel Deaconess Medical Center seeks a highly motivated research assistant with a strong molecular biology and biochemistry background at the B.S. or equivalent level to assist with laboratory work using modern and cutting edge molecular biology and biochemical techniques such as PCR, Gel Electrophoresis, Western Blotting, Immunohistochemistry, and the development of new antibody-based protein microarray technologies. The position is available immediately but undergraduates graduating in the spring will also be considered beginning in the summer. Our laboratory is affiliated with Harvard Medical School and the Beth Israel Deaconess medical center. We are a team of world leading researchers with diverse scientific backgrounds studying the molecular basis of cell growth and metabolism in cancer and metabolic disease.
The successful candidate will be immersed in an intellectually rich environment of cutting edge, world-leading research, and will be able to participate in many educational opportunities such as attendance of weekly seminars from leading researchers, literature surveys studying newly published research, and brainstorming sessions among colleagues that focus on current findings and future directions. The possibility exists for co-authorship on publications from the contributed projects as well the potential opportunity to pursue an independent project that complements the laboratories research focus. The position is ideal for recent graduates considering graduate or medical school and will provide solid experience for a future career in scientific research or medicine. Our previous research assistants have been highly successful in gaining admission to top medical schools and Ph.D programs. A two-year commitment is recommended and at least a one-year commitment is required.
BASIC REQUIREMENTS:
B.S. or equivalent in a science related major
Must have a strong undergraduate background in molecular biology with excellent laboratory skills.
Must be willing to work morning hours.
Please submit your CV, a brief cover letter including career objectives and three contacts for references.
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Research Assistant / Technician - Dana-Farber Cancer Institute (Longwood Medical Area)
By | December 22, 2008
Job Summary
Duties and Responsibilities:
A new laboratory being formed by Rameen Beroukhim at the Dana-Farber Cancer Institute seeks a research assistant to join in efforts to apply cutting-edge genomic technologies to determine optimal treatment strategies for patients with brain and other cancers. The aim of these efforts will be to initiate and conduct clinical trials in which the genomic features of patients and their tumors are robustly determined and used to fashion rational treatment. To that end, the individual will engage in experiments involving genomic DNA/RNA isolation from cancer tissue, preparation for microarray analyses, and nucleic acid amplification. The predictive value of these genomic assays will also be assayed in laboratory-based model systems, for which the individual will engage in functional experiments that apply cell culture techniques, recombinant DNA and gene transfer methods, and other cell biology assays (Western blots, immunoprecipitation, etc.).
Job Qualifications
Required Education, Experience, and Skills:
A minimum of a Bachelors Degree or equivalent is required, preferably in the Biological or Biochemical Sciences. Prior research experience in pathology, molecular biology, or genetics is preferred. In particular, experience with tissue (histological examination and dissection), DNA/RNA purification, PCR amplification, subcloning, or retroviral transfection is a plus. The ideal candidate will be comfortable in a team environment, enthusiastic about scientific discovery, and highly self-motivated. A minimum two-year commitment is required.
Schedule
Full-Time
Qualified candidates should e-mail or send a hard copy of a cover letter, resume, and the complete contact information for at least two references.
Hard copies may be sent to the following address:
Dr. Rameen Beroukhim
c/o Mr. Michael A. Donohoe
Department of Cancer Biology
Dana-Farber Cancer Institute
44 Binney Street, SM 1036
Boston, Massachusetts 02115
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Jr. Technical Project Manager — Digital Publishing (Boston, Backbay)
By | December 15, 2008
Job Summary:
We are seeking an experienced technical project manager to work directly with the program manager in a technical consulting role. The project manager will determine with PM how issues/risks will be tracked, documented, & communicated; ensure that all Business Requirements are aligned with the Chartered scope; establish a Technical Analysis Plan and determine the tool(s) that will be used, and the artifacts that will be delivered, as part of the Technical Analysis; review the technical analysis documentation for functional completeness with the Solution Architect; signoff on the Artifact Approval Summary for Technical Analysis; work directly with the Designer and/or Data Analyst to ensure all appropriate high level design documentation is created; coordinate the review of the high level design with the architect, and obtain the architect’s approval on the Artifact Approval Summary; define High level testing strategy; complete the necessary forms (websites, databases, security); request testing environments and manage them; manage development deliverables; tracking Project Change Requests (PCR); coordinate changes to production code; initiate creation of the Implementation / Release Notes (cutover / handover doc); project development information document created; code reviews completed (signoff on Artifact Approval Summary); ensure that all SOX considerations have been addressed; implementation Planning; run the point for any technical issues during the warranty period.
Experience or exposure to Java web development environments, Windows and Unix servers, Spring, Oracle, & Macromedia Flash.
This coordinator should be self-motivated and self-directed.
Knowledge, Skills and Abilities Required
High level of adaptability to changing requirements and willingness to learn new skills
Strong interpersonal skills and ability to deal effectively in a team environment
Excellent relationship building skills
Meticulous attention to detail and adherence to deadlines are essential
Ability to work independently and prioritize work
Proactive multi-tasker who can manage details in a fast-paced, deadline-driven environment;
Analytical and problem solving skills
Education & Experience:
Bachelors degree preferred, but not required
2 - 5 years experience in project coordination
Organizational and computer skills, including Microsoft Project, Excel, Word, and Outlook
ABOUT US
Xplana Learning is committed to providing meaningful educational experiences to people all over the world. Our goal is to create educational software that allows teachers to focus on teaching, and students to concentrate on learning. We believe that while technology is a key component in instructor and student success, it should blend with human touch and imagination rather than disrupt them. Our strategy is based on the creation of learning experiences that can be stored, retrieved, and repurposed or displayed in a variety of platforms.
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Technical Assistant (Broad Institute of MIT and Harvard) (Cambridge - near the Kendall T stop)
By | December 11, 2008
The Broad Institute of MIT and Harvard seeks a TECHNICAL ASSISTANT, Broad Institute-Medical and Population Genetics Program (MPG), to work with a multidisciplinary team focused on elucidating the genetic basis of complex disease. Specifically, experiments will involve high-throughput SNP genotyping and emerging DNA sequencing technologies and the employment of cutting-edge genetic methodologies and analytical strategies. Will work on disease studies related to Crohn’s disease, Type 2 diabetes, autism, and various mouse genetics projects. Experiments will include setting up high-throughput SNP genotyping and sequencing using robotics; engaging in analysis of genetic SNP data; assisting in validating novel loci; preparing, handling, and tracking patient DNA samples for various disease projects; and DNA preparation, whole genome amplification and purification, PCR, and gel electrophoresis. Will perform related duties as requested.
REQUIREMENTS: a bachelor’s degree in biology or related field; at least one year of experience in a molecular biology laboratory or on an independent research project; familiarity with basic molecular biology and sterile techniques and with the operation of standard lab equipment; excellent analytical and communication skills; and ability to interact professionally with staff at all levels in a dynamic and collaborative environment. Excellent organization and time management skills and the ability to balance a variety of project goals required. Must be independent and comfortable working on multiple genetic analysis projects at various stages and levels of involvement. Knowledge of fundamental genetic principles and computational approaches a plus.
Interested applicants may apply online at http://www.broad.mit.edu/info/careers/ and reference job number MIT-00006149. Please indicate that you located this position on Craigslist.org
PROFILE: the Broad Institute was founded to empower scientists of all kinds to work together on difficult, diverse, critical genomic and biomedical challenges. The Institute offers comprehensive benefits including:
* Competitive pay
* Medical, dental, life insurance plans
* 401(k) plan with matching contributions
* Tuition assistance plan
* Four weeks of vacation after one year
* T-Pass subsidy program
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Research Tech I Position (Cambridge)
By | December 9, 2008
We are currently looking for entry-level research techs to work in offshoot biotech comapny. At least 1 year experience in industry is desired.
Must be familiar with:
-GLP regulations/Aseptic technique
-Mammalian cell cultures
-Gel Electrophoresis
-PCR
Please send resume and cover letter.
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Nucleic Acids Biochemist/ Molecular Biologist (Medford, MA (Boston-area))
By | December 5, 2008
Please fully fill out our online application and upload your cover letter and resume to http://nanobiosym.iapplicants.com, or your application will not be considered.
DESCRIPTION OF COMPANY:
Nanobiosym is an innovative young company in Medford, MA founded by an MIT/Harvard alum to work at the interface of nano- and bio- technologies. The company is creating breakthrough scientific insights and revolutionary technologies that emerge from the convergence of physics, nanotechnology, and biomedicine. Nanobiosym (NBS) works symbiotically with its commercial partner Nanobiosym Diagnostics (NBSDx) to discover, develop, and commercialize cutting-edge technologies at this interface. NBSDx is currently developing nanobiotechnology platforms that address global healthcare needs. NBS is a truly exceptional company that has received widespread recognition. This hypergrowth company allows for unique career opportunities with strong long-term incentives.
JOB DESCRIPTION:
Nanobiosym® is currently looking for top notch candidates to build its world class Nucleic Acid Biochemist/Molecular Biologist team. Candidates will work with its multidisciplinary team to develop, characterize and troubleshoot protocols for biochemical assays in nano-platforms, single molecule biophysics and Nano Biotechnology. Efforts include optimization of biochemical assays, surface chemistry and immobilization techniques for proteins and nucleic acids.
QUALIFICATIONS:
PhD in Biochemistry, Molecular Biology, Biomedical Engineering or related field with 7+ years relevant research experience.
Research experiences in replication and transcription and other DNA protein interactions.
Demonstrated success in developing and optimizing in vitro enzyme assays.
Expert proficiency in the use of standard molecular biology techniques (DNA sequencing, PCR, cloning, and mutagenesis).
Experience immobilizing biomolecules into various surfaces.
In addition to impeccable technical skills, successful candidates should possess strong organizational and communication skills, as well as be able to work within a team and thrive in a fast-paced start-up environment.
PERSONAL QUALITIES:
The ideal candidate will be:
Excited to work in a hypergrowth company;
Extremely motivated and be willing to work in a fast-paced environment, and hard-working team;
Committed and enthusiastic about Nanobiosyms mission and programs;
Resourceful and flexible;
Adept at planning, prioritizing, multi-tasking, organizing and following through, while remaining highly energetic and focused;
Straightforward, self-motivated, and trustworthy;
Energetic and willing to work hands-on in developing and executing a variety of activities.
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Microfluidics Engineer/MEMS (Medford, MA)
By | December 5, 2008
Nanobiosym, Inc is seeking strong candidates to work in a dynamic team environment of physicists, engineers, and other scientists. The job responsibility will primarily include developing, designing, characterizing and troubleshooting microfluidics and bio-mems based systems.
Only applications submitted to http://nanobiosym.iapplicants.com will be considered.
JOB DESCRIPTION:
Nanobiosym, Inc is seeking strong candidates to work in a dynamic team environment of physicists, engineers, and other scientists. The job responsibility will primarily include developing, designing, characterizing and troubleshooting microfluidics and bio-mems based systems.
POSITION REQUIREMENTS & SKILLS:
MS or PhD in Biomedical Engineering, BIO-MEMS, microfluidics engineering or related field with 5+ years relevant post-graduate research experience.
Extensive hands-on experience required in executing, optimizing and troubleshooting current surface chemistry molecular biology techniques (DNA sequencing, cloning, and mutagenesis).
In addition to impeccable technical skills, successful candidates possess strong organizational, communication and team skills, and thrive in a fast-paced start-up environment
Expert proficiency in the use of standard molecular biology techniques (DNA sequencing, PCR, cloning, and mutagenesis).
Proficiency in use of CAD software and other Bio-MEMS design and simulation software.
Experience with a wide variety of Fluidic devices (ie flowcells and other microfluidic systems), preferential cell sorting, sample preparation techniques, manipulation and filteration of cells in microfluidic formats.
PERSONAL QUALITIES:
The ideal candidate will be:
Excited to work in a hypergrowth company;
Extremely motivated and be willing to work in a fast-paced environment, and hard-working team;
Committed and enthusiastic about Nanobiosyms mission and programs;
Resourceful and flexible;
Adept at planning, prioritizing, multi-tasking, organizing and following through, while remaining highly energetic and focused;
Straightforward, self-motivated, and trustworthy;
Energetic and willing to work hands-on in developing and executing a variety of activities;
Able to work 6 days/week;
Preference given to candidates who can start immediately.
Only applications submitted to http://nanobiosym.iapplicants.com will be considered.
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RESEARCH TECHNICIAN-BROAD INSTITUTE OF MIT & HARVARD (Cambridge-Near the Kendall T Stop)
By | December 2, 2008
The Broad Institute of MIT and Harvard seeks a RESEARCH TECHNICIAN, to join a high-throughput team actively involved in targeted high-throughput gene expression studies. Performs bench level experiments to assist with projects aimed at managing the Expression Platforms technical processes in order to ensure the output of high quality RNA profiling data. Responsibilities will include setting up chemistry reactions using robots, monitoring quality control of reactions, and reporting weekly summaries of lab observations and empirical data. Will employ a variety of genomic techniques, including RNA handling, preparation and storage of RT and PCR reactions and operation of various liquid handling devices and sensitive laser scanners. The work relies heavily on laboratory automation, UI interaction, databases, and SOPs. The role is part of a fast-paced team environment and work must ensure support of current team goals and practices by producing high-quality genetic data, active involvement in troubleshooting experiments, maintenance of a notebook and daily tracking sheets, and data file management.
REQUIREMENTS: Bachelors degree in Biology or related field required and at least one year of lab experience with genomic technologies and analysis preferred or equivalent combination of education and experience. Familiarity of basic laboratory techniques and principles of molecular biology required; some research experience in addition to degree-related lab work preferred. Hands-on experience with liquid handling automation and integration preferred. Solid knowledge of computers and experience with Excel and databases required. Excellent organizational, time management, and written and verbal communication skills required. Must be able to juggle several tasks at once and thrive in a fast-paced environment. Must be able to work independently, using sound judgment to handle a variety of tasks and effectively solve problems with minimal supervision and work as part of a team.
Interested applicants may apply online at http://www.broad.mit.edu/info/careers/ and reference job number MIT-00006108. Please indicate that you located this position on Craigslist.org. EOE.
PROFILE: the Broad Institute was founded to empower scientists of all kinds to work together on difficult, diverse, critical genomic and biomedical challenges. The Institute offers comprehensive benefits including:
* Competitive pay
* Medical, dental, life insurance plans
* 401(k) plan with matching contributions
* Tuition assistance plan
* Four weeks of vacation after one year
* T-Pass subsidy program
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(08-049) BioAssay Development Associate (Cambridge)
By | December 1, 2008
Acambis is a leading vaccine company developing novel vaccines that address significant unmet medical needs or substantially improve standards of care. ChimeriVax-JE, Acambis most advanced product in its development-stage pipeline, has to date shown an excellent safety and efficacy profile following pivotal Phase 3 trials. It is currently undergoing paediatric trials in the endemic region and is partnered with Sanofi Pasteur. Acambis proprietary ChimeriVax technology, developed in association with St Louis University, has also been used to develop ChimeriVax-West Nile, which is undergoing Phase 2 clinical testing, making it the most advanced investigational vaccine against the West Nile virus. Acambis has established a global collaboration with Sanofi Pasteur for further development and commercialisation of the vaccine. ChimeriVax has also been applied to development of Sanofi Pasteurs tetravalent dengue vaccine, which has successfully demonstrated proof-of-concept in a Phase 2 trial by generating 100% seroconversion to all four dengue virus serotypes.
Acambis ACAM-CDIFF is the only vaccine in development against Clostridium difficile bacteria, a leading cause of hospital-acquired infections. C. difficile is estimated to cause at least 360,000 cases of C. difficile-associated disease in the US alone, and annual costs to US and European healthcare systems are estimated to be in excess of $7bn a year. Acambis influenza programme aims to develop a universal vaccine against influenza, for which a universal A strain vaccine, ACAM-FLU-A, was recently tested in a Phase 1 trial and pre-clinical challenge study. Acambis is currently undertaking pre-clinical testing of a vaccine candidate, dl5-29, against genital herpes.
Acambis is recognised internationally as the leading producer of smallpox vaccines for emergency-use stockpiles held by the US Government and several other governments around the world. Acambis developed its ACAM2000 smallpox vaccine under contracts with the US Government.
On September 25, 2008 Acambis was acquired by Sanofi Pasteur, the vaccines division of the sanofi-aventis Group. Acambis is now a wholly-owned subsidiary of Sanofi Pasteur Holding, the parent company of Sanofi Pasteur. The acquisition was a logical and strategic step for both organizations, building upon Sanofi Pasteur and Acambis decade long partnership to develop novel vaccines. The integration of Acambis discovery and development capabilities into Sanofi Pasteur will strengthen Sanofi Pasteurs research powerhouse and feed future growth.More information is available at www.acambis.com.
Our Cambride, MA office is looking for a BioAssay Development Associate for hands-on contribution in planning and executing development and optimization of quantitative and qualitative nucleic acid based methods for vial and bacterial vaccine candidates. The position will act with minimum guidance or independently within generally defined practices and policies in selecting approaches and techniques.
Job Responsibilities:
Participate in development and optimization of quantitative and qualitative nucleic acid based (including Real Time-PCR) methods for viral and bacterial vaccine candidates
Perform testing in support of Process and Formulation Development function in the company.
Participate in assay/reagent qualification and non-GLP stability testing of the products for various projects.
Manage computer and sample databases; maintain lab notebooks and other required documentation associated with assay development and stability testing.
Take part in the maintenance of Instruments and Equipment in a development laboratory.
Maintain an appropriate level of familiarity with the scientific literature and new technology in order to contribute companys development efforts.
Participate in group and project team meetings, sharing data and contributing technical expertise if required.
Perform other duties as assigned.
The right individual needs a BS/MS degree in a relevant scientific discipline or equivalent with a minimum of 4-5 years experience in instrument based Q-PCR (real time) assay development, assay validation or Quality Control environment. Experience in working with viruses, bacteria, proteins and nucleic acids are important as well as understanding of safe lab practices and BSL requirements while working with live microbes and microbial products. Understanding of regulatory and compliance requirements is a plus; understanding of vaccine development, date acquisition/processing/reporting and validity of the approach is also a plus. Excellent inter-personal and verbal/written communication skills, self-motivation and diligence are highly desired.
CONTACT INFO:
Human Resources
Acambis Inc.
38 Sidney Street
Cambridge, MA 02139
E-mail: careers@acambis.com
Interested applicants must apply on-line attaching a word document to your email submission
Acambis Inc. provides a competitive salary and a full range of benefits.
We are proud to be an equal opportunity employer, dedicated to promoting a culturally diverse workplace.
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