Research Assistant/Associate (menlo park)
By | March 10, 2010
DNA2.0 is a rapidly growing synthetic biology company and is today the largest US provider of synthetic genes. We now seek a research assistant/associate to support our gene manufacturing group. The company has an exciting and dynamic work environment with many opportunities for personal and corporate growth.
The position entails synthetic gene manufacturing within a dedicated team. The work includes following standard operating procedures for gene synthesis, molecular biology methods and DNA Sequencing. The individual will also interact with our bioinformatics department.
The candidate should have broad, demonstrated skills in molecular biology, particularly in the areas of PCR, cloning and DNA sequencing analysis. Experience with automated liquid handling stations, DNA synthesis platforms and basic programming skills are a plus. The candidate will be hands on, possess excellent communication and organization skills, strong interpersonal skills, a desire to work in a team environment, the ability to contribute intellectually to the projects, and the ability to complete projects under strict deadlines. The ideal candidate should, furthermore, be comfortable working in a fast-paced setting while retaining impeccable organizational skills.
Requirements:
Qualified candidates will posses a Bachelors degree in Biology or related field with molecular biology/biotechnology experience (1-3 years).
Excellent salary and benefits, which include health, dental, paid holidays, vacation, stock options and a 401(k) plan. EOE
For more information, see www.DNA20.com.
Please send applications to hr@dna20.com. Phone calls NOT accepted.
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Senior Scientist (san carlos)
By | March 5, 2010
Artemis Health is an early-stage company dedicated to the development of non-invasive prenatal diagnostic tests. Our mission is to develop diagnostic tests that provide women, their families and healthcare providers with accurate and timely information about fetal and maternal health. We do this by developing and commercializing non-invasive and accurate prenatal diagnostic tests for use in early pregnancy, for all women.
Our company is located in San Carlos, CA. We are looking for talented people with proven skills in their discipline who enjoy working in a collaborative environment to further advances in maternal and fetal health care. This opportunity to work within a small entrepreneurial team offers tremendous growth opportunities, with competitive benefits and compensation.
We are seeking a Senior Scientist who is highly motivated to join our team in developing non-invasive prenatal genetic screening products.
Job Description:
- Perform/optimize and validate laboratory procedures associated with plasma DNA isolation from maternal blood and downstream genetic analyses.
- Develop and launch new diagnostic products and technologies by initiating, directing and executing scientific research and/or development strategies within the research team or via individual studies.
- This role is expected to manage several projects and direct reports; be highly flexible and deliver results against aggressive timelines.
Requirements:
- Ph.D. in molecular biology, genetics or related field.
- Minimum 3-5 years industrial experience in diagnostics assay development or biotechnology product development required.
- Experience in genetic and/or genomic analyses, including quantitative PCR, STR or SNP assays, familiarity with digital PCR e.g. the Fluidigm chip platform preferred.
- Experience in next generation sequencing (Solexa/Illumina platform) and data analysis strongly desired.
- Demonstrated ability to be well organized, work independently, plan and execute experiments and interpret results to high scientific rigor.
- Excellent communication, organizational, problem-solving and time management skills are essential.
To be considered for this opportunity, please submit your resume to hr@artemishealthinc.com.
Artemis Health, Inc. is an equal opportunity employer.
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Staff Research Associate II (pacific heights)
By | March 4, 2010
The Korn Laboratory at the UCSF Helen Diller Family Comprehensive Cancer Center and the Division of Gastroenterology is seeking a highly motivated, dynamic individual with strong background in cellular and molecular biology to work as a staff research associate with post-doctoral fellows. The candidate will join a highly skilled and collegial team of scientists. The laboratory is dedicated to the development of new cancer treatment strategies based on in-depth understanding and rational targeting of signal transduction pathways.
Responsibilities:
Cell culture maintenance and experimentation
RNA and protein expression analysis (PCR, Western blotting, Luminex assays, FACS analysis)
Immunofluorescence microscopy
Cell viability analysis
Maintenance and ordering of lab supplies
Qualifications:
Graduation from college with a BS or BA degree in biomedical or physical sciences
Experience with basic laboratory techniques, including DNA, RNA, and protein isolation, PCR, Western blot analysis, mammalian cell culture
computer (Macintosh or PC) literacy
facility with scientific English
The application should include current CV as well as three references with contact information.
UCSF is an Equal Opportunity/Affirmative Action Employer. The University undertakes affirmative action to assure equal employment opportunity for underutilized minorities and women, for persons with disabilities, and for covered veterans. All qualified applicants are encouraged to apply, including minorities and women.
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Lab technician/lab manager position at UCSF (inner sunset / UCSF)
By | March 2, 2010
The Engel laboratory in the Microbial Pathogenesis and Host Defense program at UCSF is seeking a talented and highly motivated individual with a strong background in Cell biology and Microbiology to serve as our laboratory manager and to provide experimental support for our postdoctoral fellows with their projects. The laboratory is an exciting, collaborative, and dynamic environment that uses cutting edge research techniques to investigate the interactions between bacterial pathogens and host cells with a special emphasis on Pseudomonas and Chlamydia infections
Responsibilities include Lab management (ordering/organizing laboratory supplies, basic maintenance duties), Molecular biology techniques (RNA/DNA/protein isolation, blotting, PCR, cloning), Cell culture maintenance and experiments, Advanced microscopy including indirect immunofluorescence, confocal microscopy, videomicroscopy, Supervision of lab assistant.
Qualifications: Bachelor in Biology or related discipline, with at least 3 years of lab experience; Willingness to make a minimum 2 year commitment to the laboratory; Knowledge of general laboratory techniques that include: PCR; DNA, RNA, and protein isolation, cloning DNA, mammalian cell culture, bacterial culture, sterile technique; Experience in microscopy; Computer proficiency with both Mac and PC platforms; motivated and detail oriented individual who works well in a highly collaborative environment, who readily learns new techniques, who is capable of multi-tasking, and who has strong written, verbal, data recording, and organizational skills.
The application should consist of your CV and the names of 3 references emailed to rluu@medicine.ucsf.edu. Please title your e-mail “Engel lab tech job”. Please direct questions to the same email address.
UCSF is an Equal Opportunity/Affirmative Action Employer. The University undertakes affirmative action to assure equal employment opportunity for underutilized minorities and women, for persons with disabilities, and for covered veterans. All qualified applicants are encouraged to apply, including minorities and women.
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Operations Manager - Now Available (petaluma)
By | February 25, 2010
1. Ready to work with a top notch team of clinical professionals?
2. Would you like to oversee operations in an emerging growth ambulance company?
3. Have you thought about jump starting your career with the right people at the right time?
If the answer is yes, please read on -
verihealth, inc. is seeking an Operations Manager in the Bay Area specifically in the North Bay.
_____________________________________________________________________________
Were a fully realized health services organization, revolutionizing the business of quality transportation and onsite medical services through leading-edge service, innovation and the latest technology. At verihealth, quality is more than just a marketing buzzword. Its the truth about everything we do.
verihealths field operations are supported by the finest clinical team in the business. Our highly respected physician medical directors, EMTs, paramedics and critical care nurses offer the insight, experience, and hands-on knowledge to make the right decisions at the right time.
Job Summary:
Assures the timely and safe transport of patients through effective operations management. Manages day-to-day ambulance field staff and oversight of all stations.
Job Duties:
Manages activities of the department(s) or division for which they are responsible for further attainment of goals and objectives.
Monitoring of all call volume for appropriateness and timeliness of response.
Provides daily oversight of operational functions in all ambulance stations.
Available after standard business hours to provide operational guidance and direction to clinical staff; communicates and submits observations on any activities to the management team.
Creates forms and processes proactively or identified by management or field staff.
Ensures completion of unit check offs and logs.
Acts as allied agency liaison.
Oversees fleet maintenance.
Actively involved in employee relations and performance reviews including discipline and counseling in direct partnership with Human Resources.
Oversight of ALS and CCT Programs including QA/QI components.
Provides PCR audits for Advance Life Support calls, all Basic Life Support to Emergency Department, standbys, and UO.
Coordinates on-boarding Paramedic training process to include accreditation steps.
Provides ongoing and mandatory operational training in conjunction with Program Coordinators including classes and online courses and exams.
Manages Field Training Officer program; coordinates meetings, schedules, and assists with any training; works with HR/Operations Coordinator.
Provides oversight for Critical Care Transport program; equipment, training (new and on-going), protocols, communication, meetings and on-call availability.
Oversees narcotic ordering while maintaining daily logs and inventory; works with DEA requirements.
Partners with management to conduct new hire orientation and training.
As necessary, staffs ambulance and performs EMT or Paramedic duties and functions.
Accounts for operational scheduling in conjunction with Human Resources while utilizing verihealth technology tools.
Participates in formulating and administering the organizations policies and developing long-range goals and objectives.
Confers with CEO and other management staff to review objectives as a result of status and condition changes.
Serves as member of management committees on special studies
Represents the company at trade association and community meetings to further market.
Serves as a member of management committees on special studies
Assists with related special projects as required.
Performs other duties as assigned by manager.
Requirements:
Any combination of education, training, or experience that provides the required knowledge, skills, and abilities.
Associates degree in related field (public safety) or equivalent; bachelors degree with additional education in business administration preferred.
Minimum of five years experience in the medical/healthcare management field.
BLS or ACLS certifications required.
Hold and maintain current emergency medical technician and/or paramedic certification.
Maintain the required annual continuing medical education credits as set forth by the State EMS Office.
Current and valid driver’s license
American Red Cross CPR for the Professional Rescuer and/or American Heart Association BCLS certification
EVOC/EVDT certification
Hazardous Materials R & I
Ability to demonstrate a high level of professionalism in dealing with confidential and sensitive issues.
Excellent verbal and written communication skills.
Ability to communicate professionally and effectively in person, on the phone, electronically, or through other means to individuals and groups
Proficient on Microsoft Office Suite.
Commitment to excellence and high standards.
Strong organizational, problem-solving, and analytical skills; able to manage priorities and workflow.
Strong interpersonal skills.
Ability to understand and follow written and verbal instructions
Compensation and Benefits:
Salary Negotiable
Medical, Dental, Vision, Direct Deposit, 401K eligibility, Paid Time Off, EAP, free recertification courses at our well-established Training Institute need we say more.
If you are interested in applying for this new Operations role go to our website www.verihealth.com. Please complete an application and submit with your resume to careers@verihealth.com or fax to 707-303-8044. Also, learn more about what verihealth, inc. solutions in healthcare is providing to the community.
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Research Associate for Dynamic Bio-Tech Company! (vallejo / benicia)
By | February 25, 2010
AcroMetrix, with facilities in Benicia, California and Alkmaar, The Netherlands, is the number one provider of molecular quality control standards and controls for clinical diagnostic and blood testing laboratories. AcroMetrix maintains this leadership role by consistently developing innovative standards, external run controls, and validation kits for molecular and serological testing in blood screening and clinical diagnostic laboratories. We take pride in our work knowing we make a difference in treatment decisions for patients and the lives of others.
AcroMetrix employees are the reason for our success. AcroMetrix’s Values reflect what is truly important to us as an organization and are the underpinning of our company culture. Our values are: Integrity, Trust, Learning, Excellence, Team Work and Fun. Many people feel AcroMetrix is an exciting company of which to be a part and a very special place to work. These Values are the primary reasons for this feeling.
The Product Specialist is responsible for creating and maintaining marketing programs and campaigns. This individual will develop and set strategic messaging, positioning, tactical plans for campaigns and product launches. This individual will develop product bulletins, brochures, proportionals, web pages, newsletters and application notes.
Position Description
The Research Associate will lead R&D activities aimed at developing and improving methods for manufacturing and QC testing. The products he or she will work on include controls, calibrators, standards and reference materials for in vitro diagnostic assays. The Research Associate will generate data to validate manufacturing ranges, process parameters, qualify critical raw materials and will also be responsible for generating stability plans, data and spreadsheets. Activities will include working with HIV, HBV, HCV, CMV, EBV, HPV other pathogens as well as human genomic material. The Research Associate must understand the importance of customer and product requirements and will write, execute and track product validation protocols against requirements. A key activity will be the independent transfer of products into manufacturing and QC including documentation.
Essential Duties and Responsibilities
1. Plan, conduct and document R&D experiments.
2. Working within the ISO 13485 and FDA QSR compliant AcroMetrix Quality System.
3. Design and write product validation test plans.
4. Develop, write and validate SOPs (in particular testing protocols and manufacturing protocols).
5. Conduct qualitative and quantitative nucleic acid assays using standard nucleic acid technologies, including real-time PCR methods.
6. Prepare chemicals, solutions and reagents for routine use within the laboratory.
7. Maintain the laboratory in an orderly fashion; keep track of materials and supplies within the laboratory and order replacements as needed.
8. Conduct routine maintenance and troubleshooting of laboratory equipment.
9. Maintain an up to date and clearly written laboratory notebook.
10. Understand and comply with AcroMetrix health and safety polices and Federal, State and local regulatory and safety guidelines and requirements.
11. Complete all other duties and responsibilities as may be assigned.
Qualifications
To perform this job successfully, the individual must be able to perform after training each essential duty satisfactorily. The requirements listed are representative of the knowledge, skill and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Knowledge, Skills and Experience Required
1. Ability to work in a diverse team and contribute to a positive work environment.
2. Solid scientific background and understanding of basic statistical concepts.
3. Excellent general laboratory skills, including routine biochemistry, molecular biology and nucleic acid chemistry techniques.
4. Documentation of experiments so they can be reproduced. Quality of documentation must be good enough to support patent claims.
5. Experience with diagnostic product optimization and development is a plus.
6. Experience with commercially available diagnostic assays for viral or bacterial nucleic acids is desirable.
7. Knowledge of personal computers and common software for data analysis, such as Microsoft Excel.
8. Mechanical aptitude sufficient to perform routine maintenance and troubleshooting of general laboratory equipment.
9. Training and experience in the proper handling and disposal of biohazardous materials and potentially infectious human blood products, including materials known to contain HIV-1 and hepatitis viruses.
Educational Requirements
This position requires a Bachelors degree and some relevant industry experience or a masters degree in biological or chemical sciences.
Accountability and Scope of Authority
The Research Associate reports to a Principal or Research Scientist, of Research and Development, and is not expected to supervise other individuals within the company, except interns.
Physical Demands
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Physical Requirements:
1. Ability to sit and stand for extended periods of time
2. Sufficient dexterity to manipulate laboratory equipment and instruments
3. Ability to communicate with internal and external contacts
Work Environment
The work environment characteristics described here are representative of those that an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Characteristics:
1. Laboratory does contain hazardous materials
2. Products do contain infectious materials
At AcroMetrix, we value our employees. We offer a dynamic and challenging work environment in conjunction with a competitive compensation and benefits package.
EOE
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Staff Research Associate I (berkeley)
By | February 25, 2010
Staff Research Associate I
UC Berkeley - Main Campus
This position is in a research laboratory in the department of Molecular and Cell Biology at UC Berkeley. The focus of the lab is on genetic differences between individuals, both in the S. cerevisiae model system and in humans, that perturb regulatory networks.
The successful candidate will conduct molecular biology and genomics research in collaboration with students and postdocs. S/he will also serve as the lab manager of our research group, so s/he must enjoy taking on a leadership role in the organization of the lab.
Responsibilities:
- Develop and carry out protocols for transcriptional profiling using new high-throughput sequencing technologies
- Ordering and setup of lab supplies and equipment
- Train new lab members
Qualifications:
- Bachelor’s degree in biology-related discipline, with a minimum of three years’ laboratory experience in yeast molecular biology
- Highly motivated and responsible
- Excellent communicator who enjoys working as part of a team
- Leadership skills in the lab and experience as a senior technician with high-level responsibilities
- Human cell culture
- Nucleic acid isolation for genomic applications
- PCR, DNA oligonucleotide construct and plasmid preparation; sequencing
- Use and maintenance of pipetting robotics
- Experience with Unix computer operating system a plus (preferred).
Salary: Hiring range (annual): $34,860 (minimum) - $37,968 (maximum); For information on the comprehensive benefits package offered by the University visit: http://atyourservice.ucop.edu/forms_pubs/misc/benefits_of_belonging.pdf
First Review Date: March 6, 2010.
To Apply: Visit http://jobs.berkeley.edu, click on ’search and apply for jobs now’ and look for job number 10458.
The University of California, Berkeley is one of the world’s leading universities in research, teaching, and public service. The campus employs 2,028 faculty and over 14,000 staff in more than 130 academic departments and interdepartmental groups, libraries, museums and more than 65 interdisciplinary research units contribute to this dynamic and vital research and teaching environment.
The University of California, Berkeley is an Equal Opportunity Employer. We offer a diverse working environment, competitive salaries, and comprehensive benefits.
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UCSF SRA I (inner sunset / UCSF)
By | February 25, 2010
Staff Research Associate I position at UCSF
Overview:
The Willenbring laboratory in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF is seeking to fill a position as a Staff Research Associate (SRA I). The laboratory investigates the molecular mechanisms regulating liver regeneration and differentiated liver function with the goal of contributing to the development of new therapies for liver diseases.
We are seeking a talented and motivated individual with a strong background in biology to serve as our laboratory manager and to provide experimental support for our postdoctoral fellows with their projects.
Responsibilities:
Lab management (ordering/organizing laboratory supplies, basic maintenance duties)
Mouse colony management (genotyping/maintaining numerous strains of transgenic and immunodeficient mice)
Molecular biology techniques (RNA/DNA/protein isolation, blotting, PCR)
Cell culture maintenance and experiments
Histological studies of mouse tissue (sectioning, mounting, staining, microscopy)
Qualifications:
Bachelor in Biology or related discipline, with at least 1 year of lab experience
Willingness to make a minimum 2 year commitment to the laboratory
Knowledge of general laboratory techniques that include: PCR, DNA isolation, sterile technique. More advanced techniques will be taught on-site
Effective oral and written communication, good analytical and interpersonal skills
Computer proficiency with both Mac and PC platforms
Proven ability to multi-task in a deadline oriented environment with limited supervision
The application should consist of your CV and the names of 2 references emailed to LeeAY2@stemcell.ucsf.edu. Please title your e-mail “UCSF SRA I”. Please direct questions to the same email address.
University of California San Francisco (UCSF) is an Equal Opportunity Employer.
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Research Associate/Senior Research Associate (emeryville)
By | February 25, 2010
ProGenTech is pre-commercial stage venture backed company focused on entering the worldwide Molecular Diagnostic Market with its proprietary instrument and reagent systems in the next 24 months. The company has recently attracted a biotech industry veteran to lead the enterprise while also adding Fortune 50 diagnostics industry expertise to its Board of Directors. The company has secured key partnerships which will accelerate the route toward its targeted markets. The company now has a need for acquiring foundational talent for its strategic marketing group which will be setting forth product and market strategies critical for product launch success.
The candidate must have assay development and systems integration experience. The position is based in Emeryville, California and will be moving to Hayward in Q3 2010, with work also performed in Campbell, California. The successful candidate will play a key role in the development of products from concept to commercialization. ProGenTech Limited provides competitive salary and a full range of benefits.
RESPONSIBILITIES
Designs, plans and executes assigned research and/or development-related experiments/projects utilizing established and innovative procedures.
Applies scientific knowledge and accumulated experience to complete projects.
Works with project manager and other team members such as engineering groups to plan, execute and deliver experimental results and solutions on schedule.
Preparation of design history file reports to document development and validation studies
Serves as a resource to other departments (e.g., Manufacturing/Operations, Quality, Marketing, Regulatory Affairs), provides timely response and follow-ups.
Serve as an internal source of scientific expertise regarding assay development and system integration
Manage and analyze experimental data; present experimental results at internal meetings and scientific conferences.
EDUCATION, SKILLS, AND EXPERIENCE
Background and education in the areas of biology, molecular biology, genetics, or biochemistry.
Molecular Biology applications such as real-time PCR, reverse transcription, nucleic acid isolation, primer design, and related procedures.
Effective interpersonal skills to work in a multidisciplinary team consisting of engineers, chemists, and molecular biologists.
Assay development from product concept to commercialization.
Strong organizational, analytical and record-keeping skills.
Significant data analysis abilities including graphing and presentation skills.
Experience with systems integration involving platforms and assays.
Working knowledge of bioanalytical techniques and GLP.
Excellent written and verbal communication skills.
Experience in an ISO 13485, ISO 9001:2000 and FDA Regulated industry preferred.
Experience in a start-up environment is a plus.
If you have these qualifications and know that you will thrive in such an environment, please submit your resume for consideration.
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Open Positions at Novartis Institutes of Biomedical Research (emeryville)
By | February 19, 2010
At Novartis Institutes for BioMedical Research (NIBR), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized.
NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on early drug discovery efforts for the Oncology Disease Area and offers a variety of positions in Biology, Chemistry, and functions such as Technology, Patents, Research Sciences and other areas that support our scientific resources.
Senior Research Investigator I, Biological Therapeutics - Requisition Number: 59943BR
Lead cross-functional scientific teams focused on the discovery and pre-clinical development of antibodies and other types of biological drugs for oncology indications. Participate in project reviews, decision-making, and new technology development for the Biological Therapeutics platform at Novartis. Must have a PhD in Immunology, Oncology, or a related field with at least 8 years of postgraduate experience. Biotechnology/pharmaceutical industry experience is required, as are an in-depth knowledge of cancer-associated signaling pathways and/or models of cancer. Experience with transitioning biological therapeutics projects into the clinic preferred; strong background in Immunology a plus.
Scientist I, Biological Therapeutics - Requisition Number: 62510BR
Validate potential oncology therapeutic targets by conducting independent laboratory work, analyzing data and interpreting results. Qualified candidates will need a Bachelor’s or Master’s degree in Cell Biology, Immunology, Molecular Biology or a related field, with at least 8 years of biotechnology or pharmaceutical work experience and expertise in mammalian cell culture and protein analysis techniques, including western blotting, ELISA and flow cytometry; broad experience in transfection (siRNA and cDNA); and experience in developing and utilizing cell-based assays for analysis of proliferation, cytotoxicity and/or intracellular signaling. Experience in cancer-associated signaling pathways and/or models of cancer, experience with biological therapeutics, ADC, qPCR, and viral transduction are all desirable.
Scientific Associate II, Biological Therapeutics - Requisition Number: 62511BR
Conduct research supporting the validation of potential oncology therapeutic targets by participating in the design of experiments, analyzing data, and interpreting results. Qualified candidates will need a Bachelor’s or Master’s degree in Cell Biology, Immunology, Molecular Biology or a related field, with at least 4 years of biotechnology or pharmaceutical work experience and expertise in mammalian cell culture and protein analysis techniques, including western blotting, ELISA and flow cytometry; experience in transfection (siRNA and cDNA); and experience in developing and utilizing cell-based assays for analysis of proliferation, cytotoxicity and/or intracellular signaling. Experience in cancer-associated signaling pathways and/or models of cancer, experience with biological therapeutics, ADC, qPCR, and viral transduction are all desirable.
Research Investigator II, Translational Sciences/Histopathology, Requisition Number: 59938BR
This individual will be responsible for planning and supervising multiple research projects within an experimental pathology group. Duties will include the conception, implementation, and interpretation (including pathological assessment) of immuno-histochemistry and histology-based studies that will guide the development of new drugs to treat human cancers. Key areas of research will include investigating and evaluating target expression in normal and cancer tissues and development of assays for biomarkers and patient stratification. Candidates should have a PhD with a strong background in cancer histopathology, as well as experience in translational research.
Research Investigator I, Cancer Biology, Requisition Number: 62261BR
We are seeking a highly motivated research investigator with a strong background in oncology research and expertise in cell cycle and DNA damage repair responses. This candidate will influence the composition and quality of the global oncology early target portfolio by direct experimental contributions and by intellectual influence and impact through interactions working both locally and on globally organized target identification and validation teams and with other functional lines, including those devoted to cancer bioinformatics and to the understanding of development and cellular signaling pathways. To qualify, candidates must have a Ph.D. in Molecular Biology, Cell Biology, Genetics, or another relevant field, with at least three years of postgraduate experience; an in-depth knowledge of cancer-associated signaling pathways and/or models of cancer; an understanding of cancer genetics and the ability to effectively use bioinformatics resources; knowledge of techniques for the characterization of cancer-associated signaling pathways and functional responses in in vitro functional assays and in the generation of relevant models; and the ability to devise experimental strategies and execute them in a timely manner to produce goal-oriented results.
Research Investigator I/II, Metabolism and Pharmacokinetics, Requisition Number 60863BR
We are looking for a highly qualified Ph.D. level Pharmacokinetics scientist who will be responsible for the design, analysis, interpretation and reporting of pharmacokinetic and pharmacokinetic-pharmacodynamic studies and who will participate on multidisciplinary drug discovery teams to plan, conduct, and interpret in vitro and pre-clinical drug metabolism studies. The selected candidate will need a Ph.D. in Pharmacokinetics or a related field with 5-12 years of relevant industry experience and an in-depth understanding of all aspects of DMPK, with special emphasis on the application of pharmacokinetics in drug discovery. Additional qualifications include experience in the design and management of both routine and mechanistic animal PK studies, the ability to direct PK resources across the organization to drive drug discovery efforts, knowledge and experience with the design of experiments to define PK- PD relationships and competency using compartmental and non-compartmental analysis, and pharmacokinetic modeling and simulation expertise using predictive software. Experience working with CROs is desirable.
Research Investigator II, Structural Chemistry, Requisition No. 59934BR
This person will be an integral member of drug discovery teams, leading receptor-ligand interaction studies and working closely with the scientists in protein biochemistry, computational chemistry, medicinal chemistry, and protein crystallography to provide support for structure-based drug design. Responsibilities will include hands-on NMR data acquisition, processing, and analysis focused on assessing ligand-binding and analyzing the solution structures of proteins and protein:ligand complexes and helping to establish an in-house NMR lab consisting of a 600 MHz spectrometer with associated computing and robotics. Experience in NMR instrumentation, methods, and data interpretation as applied to ligand-based studies and a strong background in protein chemistry and/or biophysical characterization of protein:ligand interaction is required. Experience in protein biochemistry and fragment-based screening is desirable.
Research Investigator II, Biochemical Lead Discovery, Requisition No. 61427BR
We are seeking a multifaceted and driven individual with a strong scientific background and relevant expertise in the molecular discovery and characterization of small molecule inhibitors/activators of protein targets who will design, develop, and implement both biochemical and biophysical assays suitable for the identification and characterization of such compounds. These assays should elucidate the mechanism of compound action on the target and enable project teams to evaluate the compounds and develop structure-activity relationships as part of the overall hit-to-lead process. This person will also generate innovative proposals and drive the implementation of new technological approaches and capabilities, create and implement project plans, and coordinate workflow and logistics to meet project goals and milestones. Candidates will need a Ph.D. in Enzymology or a related field, with at least 6 years of relevant postgraduate industry experience and an in-depth knowledge of enzymology and biophysics. Experience with enzyme and biophysics assay development is essential and experience with multiple assay technologies, compound screening formats, laboratory instrumentation and automation, data analysis and management, and a sound knowledge of the drug discovery process is highly desirable.
Scientific Associate I/II, Protein Sciences, Requisition No. 62208BR
This person will perform routine molecular biology work, including different cloning strategies, PCR amplification, DNA isolation and manipulation, and sequence analysis; small and medium scale expression of recombinant protein in E. coli; standard protein analysis techniques (SDS-PAGE gels and Western Blots), and be familiar with performing ELISAs and other protein analytic methods. Candidates will need a Bachelors degree with at least 3-5 years of industry experience, including strong expertise in tissue culture, cloning, and other molecular biology techniques, as well as in recombinant protein expression in E. coli and insect cells and in the analysis of recombinant protein expression.
Research Investigator II, Protein Sciences, Requisition No. 62209BR
NIBR is seeking a highly motivated scientist to contribute to the pre-clinical development of targeted oncology therapeutics. This person will be responsible for leading a group of protein biochemists to support the advancement of antibody and small molecule Oncology projects from early discovery to early development. This is a hands-on bench position which includes some management and supervisory responsibilities. Specifically, this person will produce proteins for X-ray crystallography, high-throughput screening, and therapeutic antibody programs. In addition to a Ph.D. with at least 5-8 years of industry experience, candidates will need strong expertise in protein biochemistry and related technologies, as well as a demonstrated working knowledge of the pre-clinical drug discovery process.
Sr. Business Analyst, Requisition No. 61861BR
As a member of the Emeryville Research IT (NITAS) team at Novartis Institutes for Biomedical Research (NIBR), this person will partner with scientists in discovery chemistry and biology research to provide technical and scientific applications and services. Specifically, he or she will collaborate with scientists to support existing applications and methods, and assess and identify new opportunities for data management and utilization to further drug discovery and development efforts and administer enterprise applications supporting these objectives, ensuring they are running efficiently and are highly available. Requires an MS/PhD in Chemistry/Biology with a minimum of 7 years related experience or BS in Chemistry/Biology with a minimum 10 years related experience, or equivalent, along with a working knowledge of discovery research informatics systems for chemistry and biology data management and analysis, such as ActivityBase, ELN, Spotfire and Pipeline Pilot, knowledge of the drug discovery process with practical laboratory experience, and familiarity with Oracle databases and SQL.
To apply for any of these positions, please visit https://sjobs.brassring.com/1033/ASP/TG/cim_searchresults.asp?partnerid=13617&siteid=5268&AgentID=7471215&Function=runquery and click on the link for the job title.
Postdoctoral Fellowships
NIBR Postdoctoral Fellowships provide talented scientists with the unique opportunity to conduct innovative, inter-disciplinary research. Fellows have a primary mentor at NIBR, may have an academic mentor, and develop their projects in consultation with the mentor(s). In the US, positions are available in Emeryville, CA, (near San Francisco); Cambridge, MA; and East Hanover, NJ; and internationally, in Shanghai, China; Basel, Switzerland; and Horsham, UK.
For more information and to apply, please visit: http://nibr.com/careers/postdocs.shtml.
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