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EMD Serono, Inc., an affiliate of Merck KGaA, Darmstadt, Germany, is a leader in the US biopharmaceutical arena, integrating cutting-edge science with unparalleled patient support systems to improve people’s lives. The company has strong market positions in neurodegenerative diseases, MS and endocrinology. EMD Serono is also a leader in fertility treatments. With a clear focus on the patient and a leadership presence in the biopharmaceutical industry, EMD Serono’s US footprint continues to grow, with more than 1000 employees around the country and fully integrated commercial, clinical and research operations in the company’s home state of Massachusetts.
Description
Expertise in oncology with focus on solid tumors, disease understanding to support drug discovery and translational oncology research.
Responsibilities
The primary responsibilities of this position will be to provide scientific and strategic support in oncology research and to organize and manage project progression for small molecules and or/biologicals in pre-clinical development (or lead discovery)
The candidate will be expected to plan, run, and present studies for multiple projects and assist project leaders in developing scientific and technical strategies in a matrix environment
Other primary tasks include the development and implementation of phenotypic assays in tumor cells for mechanism of action studies, indication pin pointing studies to support clinical stratification plans, as well as performing assays to address drug combinations, with the overall goal of supporting discovery and pre-clinical development of lead molecules
The candidate will also be expected to participate in the design and implementation of studies for the identification of biomarkers
The candidate should provide expertise and knowledge in the area of cancer signaling and solid tumor cell biology
Education & Languages
PhD with 2-4 years related industry/research experience preferred.
Must be fluent in both written and spoken English.
Professional Skills & Experience
Knowledge of signaling networks involved in cancer
Expertise in phenotypic and mechanistic cell-based assays in solid tumor models: proliferation (monolayer and soft agar) and apoptosis assays, cell cycle profiling
Expertise in the analysis of signaling pathway modulation in solid tumor models: Western analysis, FACS-based assays
Expertise in testing drug molecules alone and in combination in tumor hallmark assays
Experience in PCR and gene expression analysis is an asset.
High level of computer literacy required, including familiarity with Excel and data analysis software
Excellent written and oral communication skills
Ability to effectively communicate and participate in multidisciplinary, cross-functional project teams
Ability to work in a constantly changing environment
Ability to manage research activities and balance working on multiple projects at once
Excellent interpersonal skills
Click the link below and open the door to the future by submitting your resume today!
I am moving and have a complete wet lab for sale in Durham! Earned over $160K/year doing contract work…now you have this great opportunity. Great for developing ELISA, PCR, lateral flow assays, protein purification, etc. Be your own boss and set your own hours! Need to sell by July 15th if possible. Here are some of the details:
Includes microfuge, Thermo Electron scanning spectrophotometer, Sorval RC-5B refrigerated HS centrifuge w/rotor, Elga ultrapure water system, Dynax 96 well EIA plate washer, Dynex MRX EIA computerized EIA reader, HEPA hood, Branson sonicator, Frig, -20C freezer, Denver mg balance, digital convection oven, common chemicals, lab benches, chairs, desks, lap tops, wireless internet, phones, disposables, and much more. Over $40,000 in equipment and supplies! Best price for the whole lab or make offers on the pieces, but these will not be sold unless I get no offer on the lab by July 15th.
Send me an e-mail, and I will send you photos! Thanks!
BioPhase Solutions specializes in recruiting top talented professionals for San Diego’s Scientific community. We are currently looking for a QC Associate to work for a leading San Diego biotechnology company.
QC Associate
Works with a QC Development team to implement transfer and QC of DNA and RNA-based kit components. Performs QC Testing on different kit components. Works on documentation of testing protocols with the goal of supporting companys movement towards implementing GMP. Responsible for upkeep of testing lab and maintenance of testing materials inventory. Organizes primer pairs, calibrants and IPCs.
Also helps support general manufacturing activities, materials management, and Quality program.
Minimum education and/or work experience requirements:
-U.S. citizen (government contracts requirement)
-A BS degree in Molecular Biology, Biochemistry, or Chemistry
-At least 2 years experience in a lab setting
-Experience working in a clean room environment a plus
-Demonstrated experience working with nucleic acids (DNA, RNA)
-Demonstrated proficiency in the use of standard molecular biology techniques, especially PCR, RT-PCR and Q-PCR
-Analytical skills a must
-Ability to set priorities and meet strict deadlines
Please email resume if interested. Also, visit our website, www.biophaseinc.com, to view additional opportunities in San Diego County!
Contribute to the development of a novel medical instrument for use in molecular diagnostics. Develop and validate computational models for the quantification of DNA using PCR and capillary electrophoresis. Develop algorithms and user interfaces for the analysis and visualization of electropherograms and PCR amplification data. Employ models of DNA thermodynamics in the design of assays to optimize the reaction chemistry. Utilize high performance computing techniques to accelerate algorithms.
Perform statistical analysis of experimental results to characterize artifacts and provide feedback on the design of the instrument and assays. Consult on statistical analysis of clinical data. Work closely with the assay development team to ensure that statistical best practices are used in the design and analysis of experiments.
Qualifications
MS or Ph.D in computational biology/chemistry, bioinformatics, statistics, mathematics, or physics
5+ years software development experience
3+ years of Java software development, including data visualization interfaces
5+ years experience in scientific or medical data analysis for experimental assays
Excellent cross-disciplinary communication skills
The candidate should have broad knowledge of molecular biology methods and computational models as well as in-depth knowledge and experience with at least one platform used for molecular analysis (e.g. gene expression, genotyping, DNA sequencing, or Mass spectrometry). The candidate should also have experience with complete application lifecycle development and demonstrated competence in software engineering. Experience with formal design control procedures is desirable.
About PrimeraDx
PrimeraDx is dedicated to the emerging field of molecular diagnostics. The company is developing multiplexed, quantitative and cost effective assays using its proprietary STAR technology implemented on the ICEPlex instrument platform. STAR combines quantitative PCR with the ability to multiplex up to 60 targets in a single sample. The Companys initial products are for infectious disease management. PrimeraDx plans to extend its focus into oncology to support cancer therapy management through diagnostic, prognostic, staging and therapeutic monitoring.
Interested candidates should send their resume to jobs@primeradx.com and include the code CL-SW0701 in the email Subject line.
A research fellow position is available at the Massachusetts General Hospital in the area of stem cell biology and developmental biology of the skin. Focus of our research is to understand molecular mechanisms underlying formation of stem cells in skin development. We are seeking a candidate with a high level of research dedication and skill, who will participate in our research efforts and will be given the opportunity to learn and to work rather independently. Applicants must have strong collaborative skills and enjoy working in a team. The candidates should be capable of a thorough understanding of cell, molecular, and developmental biology, including hands-on experience with mammalian cell culture, histological analysis, and molecular biology techniques (i.e. cloning, PCR, western blotting, Northern and in situ hybridization). Ph.D. in Biology, Molecular Biology, Biochemistry, Biomedical science, or related discipline with at least 3 years of laboratory experience is required. While not essential, prior experience with mouse transgenesis including transgenic and knockout mouse generation is highly desirable.
Applicants should send a cover letter, CV and 3 references to Masatake Osawa, Ph.D.
The MGH/Harvard Cutaneous Biology Research Center is a committed Equal Opportunity/Affirmative Action Employer. Minorities, women, handicapped and veterans are encouraged to apply.
Genetic analysis using the Affymetrix arrays (DMET, 3 IVT and whole transcript gene expression arrays). Excellent skills in experimental design, implementation, troubleshooting, and data analysis. Experience handling large datasets generated from DNA and/or Microarray analysis.
Performs RNA extraction, total RNA quality analysis and cDNA synthesis from a variety of sources including FFPE tumor samples using approved standard operating procedures.
Perform absolute and/or relative quantification of gene expression levels using real-time PCR methods.
Review of gene expression data, gene expression protocols and final reports.
Performs DNA purification and quantification, gel electrophoresis, and normalization. Performs routine and non-routine genotyping assays including DNA sequencing, gel based assays and endpoint analysis.
Performs the laboratory portion of the assay development and validation process with including optimization of PCR conditions.
Assay design for the detection human genetic variations using bioinformatic software and other appropriate resources.
Perform literature searches in support of the scientific efforts at Gentris.
Develops protocols and methods for evaluating and analyzing various types of genomics data.
Assists in the writing, editing, and implementing standard operating procedures, material requirements documents, and other essential documentation.
Mentoring and training staff in the junior scientists positions.
Communicate ongoing project/study progress and act as the key interface to clients.
Qualifications:
Minimum requirements include a Biological Science degree (BS+4, MS+2) with Industry experience, Biotech / Pharmaceutical / Drug Discovery. Candidates must have working experience with molecular biology techniques, and knowledge of advanced molecular biology techniques especially with RNA. Must be detail-oriented. Ability to think and work independently.
The Ocean Genome Legacy Laboratory for Marine Genomic Research (www.oglf.org) seeks research assistants to aid with all aspects of operation of the Ocean Genome Resource DNA repository and its associated research projects. The successful candidates will have experience and general knowledge of collection management, basic techniques of molecular biology and microbiology (e.g., DNA extraction and handling, gel electrophoresis, PCR amplification, cloning, sterile technique, bacterial cultivation techniques, etc.), and excellent computer and data management skills. Experience and knowledge of protein biochemistry is also desirable. Full- and part-time positions are available immediately.
Applicants should submit a cover letter, resume, list of publications, and contact information for at least three references by email to careers@oglf.org (referencing job code OGL-FTRA09 for full-time or OGL-PTRA09 for part-time in the subject line) or by regular mail to the address below.
Ocean Genome Legacy, Inc. is a publicly supported non-profit research organization dedicated to exploration, description, documentation, and preservation of the genomic diversity of the oceans. Located on the campus of New England Biolabs in Ipswich, MA, OGL is an equal opportunity employer that receives support from the National Science Foundation, the Department of Energy, and the National Institutes of Health.
Medarex Inc. is looking for a Research Associate 2/3 that will support the Transgenic Modeling group within the Animal Biology Research Department. Primary responsibilities will include providing technical and administrative lab support to the team developing new transgenic strains by assisting in the genotyping and phenotypic analysis of the large number of transgenic strains recently generated.
Main Job Responsibilities include, but are not limited to:
Molecular Biology:
DNA purification from various organisms (mouse tail samples, E.Coli)
PCR analysis for genotyping purposes
RNA and cDNA preparation and analysis
General recombinant DNA cloning, PCR and sequence analysis
Cellular Immunology
Basic cell culture techniques
Familiar with basic FACS staining techniques
Experience with simple ELSA techniques
Documentation
Highly organized and detailed documentation of all essential procedures, activities and results in lab notebooks and databases
Use computers/programs for data acquisition, analysis and presentation
Data entry for microinjection record keeping and analysis.
Communication
Interact well with project teams to communicate data
Oral and written communication of results to Medarex personnel in informal presentations
Strategy
Identify and troubleshoot simple procedures using critical thinking
Present ideas and assist in formulating strategies for project progression
Required Skills/Experience:
Required skills/experience includes, but is not limited to:
Basic knowledge of recombinant DNA techniques
Must be highly organized with fine attention to detail
Must posses strong skills in data analysis, problem solving, communication, computers, and multi-tasking.
Knowledge or experience with database queries, statistics, general immunology (ELISA and FACS) methods
Animal handling a plus
Bachelors degree in biological science (immunology, molecular biology, or genetics preferred)
2-5 years practical lab experience
About Medarex:
Medarex is a biopharmaceutical company focused on the discovery, development, and potential commercialization of fully human antibody-based therapeutics to treat life- threatening and debilitating diseases, including cancer, inflammation, autoimmune and infectious diseases. Medarex applies its UltiMAb® technology and product development and clinical manufacturing experience to generate, support and potentially commercialize a broad range of fully human antibody products for itself and its partners. Medarex is committed to building value by developing a diverse pipeline of antibody products to address the world’s unmet healthcare needs. To apply to the above position, please visit our website at www.medarex.com
Medarex Inc. is looking for a Temp to Hire Research Associate 3 that will work in their Animal Biology group supporting the development, characterization and application of genetically modified murine models for production of human antibodies. Job duties include, but are not limited to:
Genotyping and analysis of genetically modified murine models to facilitate internal drug development.
Perform genotyping assays by PCR analysis with either a gel-based, or Real Time PCR format.
Develop and implement new genotyping assays by Real Time PCR.
Work as part of a multidisciplinary team to define, develop, test and validate primer and probe sets as well as implementing new probe design or amplification strategies.
Depending on experience and available resources, may also have the opportunity to participate in pre-clinical in vitro studies to support drug development studies.
Required Skills/Experience:
Required skills/Experience includes, but is not limited to:
General knowledge of the principles of molecular and cellular biology.
Practical experience with techniques such as Real Time PCR, cloning, primer and probe design, electrophoretic methods, and DNA sequencing.
Experience with mammalian tissue culture is highly desirable and experience with imaging applications would be a plus.
Experience working with liquid handling machines for automation of routine laboratory protocols.
Ability to interact effectively with scientists from different departments and at different levels within the company.
Must be customer focused, team oriented, and self-motivated.
BS or MS degree in the Biological Sciences with a minimum of 5 years working experience.
Must have experience working in a setting of developing and running molecular biology assays.
About Medarex:
Medarex is a biopharmaceutical company focused on the discovery, development, and potential commercialization of fully human antibody-based therapeutics to treat life- threatening and debilitating diseases, including cancer, inflammation, autoimmune and infectious diseases. Medarex applies its UltiMAb® technology and product development and clinical manufacturing experience to generate, support and potentially commercialize a broad range of fully human antibody products for itself and its partners. Medarex is committed to building value by developing a diverse pipeline of antibody products to address the world’s unmet healthcare needs. To apply to the above position, please visit our website at www.medarex.com
